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Fosamax june 19

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  1. Bisphosphonate Use Drops After Media Reports Of Safety Concerns

    Jun 18, 2015 | Healio

    ...Researchers found “Fosamax” to be the most consistently searched term among generic and brand name bisphosphonates between 2004 and 2015, and found news articles regarding Fosamax and bisphosphonates correlating to the dates of major spikes in search frequency. “The first prominent spike was noted in 2006, when ...

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    Client Attorney Privileged/Attorney Work Product/At Request of Counsel

  1. Bisphosphonate Use Drops After Media Reports Of Safety Concerns

    Jun 18, 2015 | Healio

    Media reports calling into question the safety of bisphosphonates to treat osteoporosis led to a sharp drop in use of the drug between 2008 and 2012, according to research in the Journal of Bone and Mineral Research. 

    In an analysis of relevant media reports and Internet search trends concerning bisphosphonate use and hip fracture, along with data from national prescription drug and health care databases, researchers found that, after a decade of increasing growth, bisphosphonate use declined by 50% between 2008 and 2012 as media reports highlighted the potential for certain fractures in long-term users of bisphosphonates, such as Fosamax (alendronate sodium, Merck).

    ...Researchers found “Fosamax” to be the most consistently searched term among generic and brand name bisphosphonates between 2004 and 2015, and found news articles regarding Fosamax and bisphosphonates correlating to the dates of major spikes in search frequency.

    “The first prominent spike was noted in 2006, when the first lawsuit was filed against Merck and Co. Inc. for osteonecrosis of the jaw,” the researchers wrote. “The second spike was seen in 2008, after a study published in the Archives of Internal Medicine showed an increased risk of atrial fibrillation with use of alendronate.”

    An ABC World News program linking alendronate to atypical femur fractures in 2010 also led to an increase in the use of “Fosamax” as an Internet search term, according to researchers.

    Researchers also found a decline in bisphosphonate use primarily among white women, from 86.4% in 2008 to 78.1% in 2012 (P < .009). Less educated women also showed a significant decrease in bisphosphonate use, dropping from 15.3% in 2008 to 11.8% in 2012 (P <  .01) vs. college-educated women, as well as a significant decrease in the rural population, from 17.2% in 2005 to 12.6% in 2008 (P <  .03), compared with the urban population...

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    http://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/%7Be990cae8-cd76-4e57-84d9-a4f987fdab3d%7D/bisphosphonate-use-drops-after-media-reports-of-safety-concerns

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