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Fosamax 27/04

    Client Attorney Privileged/Attorney Work Product/At Request of Counsel

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  1. Update: Osteonecrosis of the jaw (ONJ)

    Apr 24, 2015 | Dentistry iQ

    By Maria Perno Goldie, RDH, MS

    According to the American College of Rheumatology, ONJ “is associated with cancer treatments (including radiation), infection, long-term steroid use, or potent antiresorptive therapies that help prevent the loss of bone mass.” (2) Some of these antiresorptive pharmaceuticals are bisphosphonates such as alendronate (Fosamax), risedronate (Actonel and Atelvia), ibandronate (Boniva), and denosumab (Prolia).

    Client Attorney Privileged/Attorney Work Product/At Request of Counsel

    Online Sources

  1. Update: Osteonecrosis of the jaw (ONJ)

    Apr 24, 2015 | Dentistry iQ

    By Maria Perno Goldie, RDH, MS

    According to the National Institutes of Health (NIH), osteonecrosis is a disease where new bone does not replace old, resorbing bone quickly enough. The cause is attributed to less flow of blood to the affected area. (1) Osteonecrosis can occur in any bone, but we will discuss osteonecrosis of the jaw (ONJ).

    According to the American College of Rheumatology, ONJ “is associated with cancer treatments (including radiation), infection, long-term steroid use, or potent antiresorptive therapies that help prevent the loss of bone mass.” (2) Some of these antiresorptive pharmaceuticals are bisphosphonates such as alendronate (Fosamax), risedronate (Actonel and Atelvia), ibandronate (Boniva), and denosumab (Prolia). (2)

    The American Academy of Oral Medicine (AAOM) has a question and answer page on bisphosphonate therapy and its connection to ONJ. It mentions that ONJ has been reported by those taking bisphosphonates and having a procedure such as tooth extraction or other invasive dental procedures. The AAOM considers ONJ a rare side effect for those taking oral bisphosphonates. (3)...

    ...Clinical management of patients with ONJ is best carried out using the American Association of Oral and Maxillofacial Surgeons or American Dental Association staging systems. For a complete history, explanation and suggested treatment of ONJ, view the position paper of the American Association of Oral and Maxillofacial Surgeons. (8).


    For full story: http://www.dentistryiq.com/articles/2015/04/update-osteonecrosis-of-the-jaw-onj.html

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